Tadarise 40 mg contains tadalafil, a phosphodiesterase type 5 inhibitor, that is used to treat erectile dysfunction (impotence) in men. throughout sexual stimulation, nitric oxide is released into the erectile tissue of the sex that activates the enzyme guanylate cyclase. Tadalafil in the Tadarise produces 40mg tablets on the erect matter of the penis to increase blood flow to block the action of PDE5 and cause an erection.