Thanks to the University of Minnesota for sponsoring this video! twin-cities.umn.edu/ The same enzyme that used to save us is now killing us because the body reactions it catalyzes now cause more harm than good. Thanks also to our Patreon patrons www.patreon.com/MinuteEarth and our YouTube members. ___________________________________________ To learn more, start your googling with these keywords: Cyclooxygenase: An enzyme responsible for the production of thromboxane and prostaglandins. Thromboxane: A lipid that acts as a platelet aggregator. Platelets: Special non-nucleic blood cells that clump together to cause blood clots. Prostaglandins: A lipid that causes vasodilation and inflammation. Aspirin: A form of acetylsalicylic acid that acts as an NSAID. NSAIDs: Non-steroidal Anti-Inflammatory Drugs that inhibit COX, and thus inflammation and clotting. ___________________________________________ Subscribe to MinuteEarth on YouTube: goo.gl/EpIDGd Support us on Patreon: goo.gl/ZVgLQZ And visit our website: www.minuteearth.com/ Say hello on Facebook: goo.gl/FpAvo6 And Twitter: goo.gl/Y1aWVC And download our videos on itunes: goo.gl/sfwS6n ___________________________________________ Credits: Script Writer and Narrator: David Goldenberg Video Illustrators: Ever Salazar and Sarah Berman Video Directors: David Goldenberg and Ever Salazar With Contributions From: Henry Reich, Alex Reich, Kate Yoshida, Ever Salazar, Peter Reich and Julián Gómez Music by: Nathaniel Schroeder: www.soundcloud.com/drschroeder ___________________________________________ References: Fitzpatrick, F. (2004). Cyclooxygenase Enzymes: Regulation and Function.Current Pharmaceutical Design. 10:577-588. Retrieved from: www.ncbi.nlm.nih.gov/pubmed/14965321. Dubois, R., Abramson, S., Crofford, L., Gupta, R., Simon, L., Van De Putte, L., Lipsky, P. (1998). Cyclooxygenase in biology and disease. The FASEB Journal 212(12):1063-73. Retrieved from: www.ncbi.nlm.nih.gov/pubmed/9737710. Havird, J., Kocot, K., Brannock, P., Cannon, J., Waits, D., Weese, D., Santos, S., Halanych, K. (2015). Reconstruction of cyclooxygenase evolution in animals suggests variable, lineage-specific duplications, and homologs with low sequence identity. 80(3-4):193-208. Retrieved from: www.ncbi.nlm.nih.gov/pubmed/25758350. Ricciotti, E. and FitzGerald, G. (2011).Prostaglandins and Inflammation. ATVB In Focs. 31(5): 986–1000. Retrieved from: www.ncbi.nlm.nih.gov/pmc/articles/PMC3081099/. Rao, P., and Knaus, E. (2008). Evolution of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Cyclooxygenase (COX) Inhibition and Beyond. Journal of Pharmaceutical Science. 11 (2): 81-110. Retrieved from: www.ncbi.nlm.nih.gov/pubmed/19203472. Van't Hof, J., Duval, S., Misialek, J., Oldenburg, N., Jones, C., Eder, M., Luepker, R. (2019). Aspirin Use for Cardiovascular Disease Prevention in an African American Population: Prevalence and Associations with Health Behavior Beliefs. Journal of Community Health. 44(3):561-568. Retrieved from: www.ncbi.nlm.nih.gov/pubmed/30895416. Leupker, R. (2019). Personal Communication. Minnesota Heart Health Program. University of Minnesota. Chipman, J. (2019). Personal Communication. DEpartment of Surgery. University of Minnesota.

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