Go to curiositystream.com/scishow to start streaming Breakthrough. Use the promo code ‘scishow’ during the sign-up process to get your first 31 days free. Coming up with brand new drugs is all about pinpointing and exploiting a disease’s weakness. A big part of perfecting drug design will be learning to predict how proteins get their shapes because that has everything to do with how both diseases and drugs work. Hosted by: Hank Green SciShow has a spinoff podcast! It's called SciShow Tangents. Check it out at www.scishowtangents.org ---------- Support SciShow by becoming a patron on Patreon: www.patreon.com/scishow ---------- Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Adam Brainard, Greg, Alex Hackman, Sam Lutfi, D.A. Noe, الخليفي سلطان, Piya Shedden, KatieMarie Magnone, Scott Satovsky Jr, Charles Southerland, Patrick D. Ashmore, charles george, Kevin Bealer, Chris Peters ---------- Looking for SciShow elsewhere on the internet? Facebook: www.facebook.com/scishow Twitter: www.twitter.com/scishow Tumblr: scishow.tumblr.com Instagram: instagram.com/thescishow ---------- Sources: www.pbs.org/newshour/health/the-real-story-behind-the-worlds-first-antibiotic www.cancer.gov/research/progress/discovery/gleevec www.nature.com/scitable/topicpage/gleevec-the-breakthrough-in-cancer-treatment-565 www.ncbi.nlm.nih.gov/pmc/articles/PMC4055302/ www.ncbi.nlm.nih.gov/pmc/articles/PMC5238551/ www.ncbi.nlm.nih.gov/pubmed/17921997 www.ncbi.nlm.nih.gov/pmc/articles/PMC4889822/ www.rcsb.org/pdb/results/results.do?tabtoshow=Current&qrid=69B25B99 www.ncbi.nlm.nih.gov/pmc/articles/PMC138819/pdf/gb-2000-1-1-comment002.pdf science.sciencemag.org/content/294/5540/93 www.biostat.wisc.edu/bmi776/lectures/Rosetta.pdf onlinelibrary.wiley.com/doi/full/10.1002/prot.25415 commons.wikimedia.org/wiki/File:TOP7-rosetta_superposition.png commons.wikimedia.org/wiki/File:HSQC-NMR.tiff commons.wikimedia.org/wiki/File:X-ray_diffraction_pattern_3clpro.jpg www.nature.com/articles/nrd941 commons.wikimedia.org/wiki/File:Spombe_Pop2p_protein_structure_rainbow.png www.ncbi.nlm.nih.gov/pmc/articles/PMC1186895/ www.ncbi.nlm.nih.gov/books/NBK22393/ academic.oup.com/bioinformatics/article/23/6/717/418732 Image Sources: en.wikipedia.org/wiki/Amino_acid#/media/File:Amino_Acids.svg commons.wikimedia.org/wiki/File:Imatinib_xtal-2007-balls-and-sticks.png commons.wikimedia.org/wiki/File:Bruker_Avance_DPX_250_NMR_Spectrometer.jpg