Colin Renfrew speaks on the Unsolved Mysteries of the Silk Road at the Silk Road Symposium held at the Penn Museum held in March 2011. The extent of contact between east (China) and west (Europe and Western Asia) in the prehistoric period has been much debated but remains little understood. In 1921 John Gunnar Anderson's excavations at Yangshao in Henan province led him to interpret the painted neolithic pottery found there as derived from that of neolithic Greece, a suggestion discounted by most subsequent scholars. Yet the genetics of the millet found in the neolithic of China and of eastern Europe leads archaeobotanists today to suggest a single source. The origins of copper and bronze metallurgy are likewise debated, and the mechanisms of transmission from the west of the horse-drawn chariots seen in burials of the late Shang dynasty are still open to question. Xinjiang province, with its remarkable preservation and its many insights from the second and first millennia BC offers tantalising clues, not least the Tarim "mummies" with their wonderfully preserved clothing and their western appearance. The presence there in the eighth century AD of the Tocharian language, the easternmost in the Indo-European language family, has led to intriguing speculations. These will be critically addressed. It will be argued that we are the dawn of a new era in the archaeology of prehistoric Eurasia, with the Silk Road offering challenges to many long-held ideas. Colin Renfrew is the former Disney professor of Archaeology and Director of the McDonald Institute for Archaeological Research at the University of Cambridge, Cambridge, UK. He is now Senior Fellow of the McDonald Institute. More information at www.penn.museum