A Kratom Dosage Guide. In general the dosage starts at 2-4 grams and tops out at 12-25 grams. 12-25 grams would be a very strong dose providing the most pain relief, euphoric feelings and relaxation. 2-4 grams would be a mild dose providing a more energizing and general feeling of well-being. Consult your doctor before taking any medications or herbal supplements, this is meant as a general kratom dosage guide. Visit www.MokshaBotanicals.com for more information.