How to Manage Depression--www.feelgoodforgood.com/lastingeffects.htm. Freeebook--the Best Method for Beating Depression Symptoms of Melancholic Depression Severity of melancholic depression varies, but medical researchers consider it one of the worst forms of depression because of its difficulty to treat. Those who suffer from this type of depression have the same symptoms that are often reported by those with bipolar disorder. What Are the Symptoms of Melancholic Depression? Agitation Poor Concentration Appetite Changes Lack of Empathy Numbness Extreme Fatigue See the video for an explanation of each of the symptoms.