Skopje Capital of Republic of Macedonia Skopje is the capital and largest city of the Republic of Macedonia. It is the country's political, cultural, economic, and academic center. It was known in the Roman period under the name Scupi. Wikipedia Area: 220.6 sq miles (571.5 km²) Weather: 38°F (3°C), 72% Humidity Population: 531,444 (2010)