On iTunes at itunes.apple.com/us/artist/glenn-wolkenfeld/id555040717 On Amazon at tinyurl.com/pvt5kbb Take the DNA Interactive Quiz at www.sciencemusicvideos.com/quizzes Buy the video at www.teacherspayteachers.com/Store/Glenn-Wolkenfeld-1 Get curriculum at www.sciencemusicvideos.com On twitter, twitter.com/GlennWolkenfeld for the daily bio-haiku. LYRICS: Welcome, I'm so happy you came by For a lesson 'bout the essence of b-i-o-l-o-g-y DNA's the topic, it's so fantastic, We talking 'bout Deoxyribonucleic acid If you've ever wondered 'bout development in elephants or bumble bees, coffee trees, well DNA's the recipe In its home in a chromosome in the nucleus DNA drives the bus, genetically controlling us In ferns and worms infectious germs, mommy's egg and daddy's sperm DNA's the information linking up the generations It's the code of life so listen up well, 'Cause DNA's the molecule in charge of every cell CHORUS DNA! Fantastic Deoxyribonucleic Acid We talking 'bout Deoxyribonucleic acid. DNA! Fantastic The shape is key and probably well known to you Double helix, twisted ladder, or a double corkscrew Imagine a twisted length of tape with deoxyribose sugars on the edges with phosphates Sugar phosphate sugar phosphate making up the sides of the ladder with nitrogenous bases on the inside with the bases like the rungs and together with deoxyribose sugar and a phosphate make a nucleotide Deoxyribonucleotides are the monomers link them up together for the DNA polymer Point three four nanometers marks the space between one nucleotide and the next one's place And for the helix to make one turn takes 10 bases in a row as you can discern Since space 'tween nucleotides is point three four, one turn takes nanometers three point four So stylish!, So slick! first described in fifty three by Watson and Crick and don't forget Franklin she took that famous X-Ray pic but she died so she never got her Nobel prize. CHORUS DNA! Fantastic Deoxyribonucleic Acid We talking 'bout Deoxyribonucleic acid. DNA! Fantastic The nitrogenous bases comes in one of four varieties, Known by the letters A, T, C and G A is for Adenine, Thymine's got the "T" C it stands for Cytosine and Guanine's got the "G" A and G with two nitrogen rings are purines C and T with one ring are pyrimidines C only bonds with G, A only with T Because like puzzle pieces they're complementary They fit together. snuggled up like hand and glove, like enzymes and substrates, like people in love A-T, C-G, matched up like lock and key Forming hydrogen bonds, either two or three. Hydrogen bonds, you know they aren't very strong, But they're enough to hold DNA together all day long The way the bases fit together couldn't be sweeter, they give DNA a width of two nanometers DNA's double stranded, looks pretty swell The strands' orientation is anti parallel With one standing up, the other on its head It's how they fit together, Crick and Watson said! CHORUS Sugars and phosphates make the backbone, the structure But the sequence of the bases is where you find instructions for Development of bodies and the cytoplasmic symphony, That constitutes life's miracle in goats and golden algae, Your sequence of bases is unique, a special batch, Unless you're an identical twin it's nowhere matched, And you can bet, that if you're not Jango Fett That you got no clone, no one like you's been known! Our bases comprise our individuality, You might have "A" where I might have a "G" Explaining why I'm bald and you got all that hair These differences can show up anywhere, The protein hemoglobin, now listen up well, It carries oxygen in your red blood cells, Hemoglobin's made of four protein pieces, A trait widely shared among animal species. Hundreds of bases spell one hemoglobin piece, Hundreds of A's, G's, Ts and Cs the gene starts CAC-GTG-CAC Then TGA-GGA-CTC-CTC The key is these bases are information, For hemoglobin's function and conformation, Hundreds of bases, in a predetermined order, A single change brings on a major disorder, Change T to A in one single spot This little point mutation might not seem like a lot, Thymine to Adenine might not seem that big to ya' But baby that's the cause of sickle cell anemia CHORUS

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