Executive orders, sweeping budget cuts, and other actions in the first 100 days of the Trump administration have had innumerable impacts on science in the United States and throughout the world. The scientific workforce, biomedical research, and global health initiatives all face widespread, perhaps permanent damage. Science news staff weigh in on how these changes have affected the funding and practice of scientific research, and what kinds of lasting impacts the administration may have on the global scientific enterprise. Read the rest of our Trump 100 Days coverage here: www.science.org/content/article/100-days-shook-u-s-science 0:00 Introduction 0:18 Workforce impacts 3:35 Biomedical research 6:16 Global health 9:18 Looking ahead