Parastoo Hashemi Presents Eavesdropping on the BrainMalfunctions of the brain's serotonin system are thought to underlie the symptoms of depression, primarily because antidepressants that target the serotonin transporters show some clinical success. We model the experimental data and offer mechanistic insights into how histamine and serotonin modulate one another in health and disease and this leads us to hypothesize why antidepressants are not universally effective. The data afforded by our chemical tools has the capacity to profoundly improve therapeutic strategies towards depression by shedding light on another important player.
Karen Faulds Presents Multiplexed and Sensitive Bioanalysis Using SERSSurface enhanced Raman scattering (SERS) is an analytical technique with several advantages over competitive techniques in terms of improved sensitivity and multiplexing. Here we demonstrate the development functionalized nanoparticles as sensing materials for the detection of bacteria and proteins at ultra-low levels. We achieve this by combining functionalized silver or gold nanoparticles with SERS. This combination can result in extremely sensitive and selective bio sensing with unprecedented multiplexing capabilities.
Julie Kowalski presents "Reassessing Potency Analysis"Analysis of cannabinoids is critical to the cannabis industry for product labeling and because product value is often based primarily on potency values. This work takes advantage of the selectivity of liquid chromatography- tandem mass spectrometry, LC-MS/MS, to quantify cannabinoids in a variety of cannabis matrices.