Life goes on: Living with Alzheimer'sWinnipegger David Gary Quinton speaks candidly about his life with dementia.
He recounts times when he has had mental lapses and discusses how he and his wife Judy have made changes in their lives that have raised Quinton's day-to-day quality of life.
Quinton speaks passionately about his decision to maximize his situation and live life to the fullest.
This video was co-produced by the Alzheimer Society of Manitoba and Canadian Virtual Hospice.
Inside the Brain: Unraveling the Mystery of Alzheimer's Disease [HQ]This 4-minute captioned video shows the intricate mechanisms involved in the progression of Alzheimer's disease in the brain.
http://www.nia.nih.gov
Permission to use ADEAR materials is not required. When you use our materials in print, on the Web, or in a video or audio format, we simply request that you credit the "Alzheimer's Disease Education and Referral Center, a service of the National Institute on Aging."
The human brain is a remarkable organ. Complex chemical and electrical processes take place within our brains that let us speak, move, see, remember, feel emotions and make decisions. Inside a normal healthy brain, billions of cells called neurons constantly communicate with one another.They receive messages from each other as electrical charges travel down the axon to the end of the neuron. The electrical charges release chemical messengers called neurotransmitters. The transmitters move across microscopic gaps, or synapses, between neurons. They bind to receptor sites on the dendrites of the next neuron.This cellular circuitry enables communication within the brain. Healthy neurotransmission is important for the brain to function well. Alzheimer's disease disrupts this intricate interplay. By compromising the ability of neurons to communicate with one another, the disease over time destroys memory and thinking skills. Scientific research has revealed some of the brain changes that take place in Alzheimer's disease. Abnormal structures called beta amyloid plaques and neurofibrillary tangles are classic biological hallmarks of the disease. Plaques form when specific proteins in the neuron's cell membrane are processed differently. Normally, an enzyme called Alpha-secretase snips amyloid precursor protein, or APP, releasing a fragment. A second enzyme, Gamma-secretase, also snips APP in another place. These released fragments are thought to benefit neurons. In Alzheimer's disease, the first cut is made most often by another enzyme, Beta-secretase. That, combined with the cut made by Gamma-secretase, results in the release of short fragments of APP called Beta-Amyloid. When these fragments clump together, they become toxic and interfere with the function of neurons. As more fragments are added, these oligomers increase in size and become insoluable, eventually forming Beta-Amyloid plaques. Neurofibrillary tangles are made when a protein called tau is modified. In normal brain cells, tau stabilizes structures critical to the cell's internal transport system. Nutrients and other cellular cargo are carried up and down the structures called microtubules to all parts of the neuron. In Alzheimer's disease, abnormal tau separates from the microtubules, causing them to fall apart. Strands of this tau combine to form tangles inside the neuron, disabling the transport system and destroying the cell. Neurons in certain brain regions disconnect from each other and eventually die, causing memory loss. As these processes continue, the brain shrinks and loses function. We now know a great deal about changes that take place in the brain with Alzheimer's disease, but there is still much to learn. What other changes are taking place in the aging brain and its cells and what influence do other diseases, genetics, and lifestyle factors have on the risk of developing Alzheimer's disease as the brain and body age? Scientific research is helping to unravel the mystery of Alzheimer's and related brain disorders As we learn more, researchers move ever closer to discovering ways to treat and ulimately prevent this devestating, fatal disease.
Drugs for Alzheimer's diseaseMedication is available to treat the symptoms of Alzheimer's disease. Consumer Reports Best Buy Drugs says for most people, the drugs are not very effective. Find more info here: http://www.consumerreports.org/health/best-buy-drugs/alzheimers.htm
Alzheimer's Disease-Related Dementias: Research Challenges and OpportunitiesRecommendations from the NIH-hosted Alzheimer's Disease-Related Dementias: Research Challenges and Opportunities meeting in May, 2013 will shape research priorities for years to come.
Living With Alzheimer's Disease: Florence & LindaThis is the story of Florence and Linda of Las Vegas, a mother and daughter that are battling Alzheimer's Disease together. Cleveland Clinic Lou Ruvo Center for Brain Health provides outstanding support services for caregivers and clinical care for patients.
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How to Prevent Alzheimer's Disease and Dementia - intro to new concepts (Part 1/6)This is the first video in a series that will explain to you what you need to do to prevent Alzheimer's disease and how to prevent dementia. The Dementia Prevention Center has over a decade of experience in the prevention of dementia. Prevention of Alzheimer's and dementia, Reversal of Alzheimer's and Dementia, and also the ability to keep Alzheimer's disease and dementia from getting any worse (at times for more than a decade). This video series has new scientific and medical concepts that need to be briefly introduced, as some of the information will be different from what you have been reading and have been told. Allen J. Orehek, M.D. is the innovator at the Dementia Prevention Center and has developed new concepts, published a new hypothesis on the cause of Alzheimer's disease and dementia, and has coined a new medical term (Micron Stroke). The video series is designed to explain all of the details to non-medical people. The language and explanations are in simple to understand English. We are happy to respond to all questions. As Dr. Orehek explains, "I am a doctor, I am not YOUR doctor" - this video series is provided to you as medical information that you will then be able to go back to your health care team and get proper treatment. For one looking at options for prevention of Alzheimer's disease or dementia, or those who have the problem and want a more detailed explanation and investigation to discover why their brain is being damaged - this video series is designed for you! This is all about you.
Contact or questions:
info@dementiapreventioncenter.com
www.dementiapreventioncenter.com
Allen J. Orehek, M.D. presents his unique talent of prevention of dementia in motivated individuals in this video series. (Intro released 1/2013)
Nutrition Prevents Alzheimer's Disease: Top 10 Preventive StrategiesIn this video Dr Meschino explains the top 10 strategies to prevent Alzheimer's disease, according to published data. For more information:
http://www.meschinohealth.com/blog/alzheimers-disease-and-cognition/2012/06/27/nutrition-alzheimers-disease-chance-prevent-its-late
Extended Interview with Alzheimer's Patient, Don Hayenhttp://www.kpbs.org/alzheimers
Don Hayen is a retired doctor and former medical director of an HMO. He was diagnosed with Alzheimer's disease in 2005, at age 71. Over the past two years, Don has coped well with the disease -- so well he's been unable to meet the requirements to take part in clinical trials of experimental Alzheimer's drugs. But his wife, Jane, notices his decline.
For more on this story visit http://www.kpbs.org/news/local;id=10889
Alzheimer's Disease: From Genes to Novel TherapeuticsAir date: Wednesday, March 23, 2011, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: Alzheimer's disease (AD) is strongly influenced by inheritance and genetic susceptibility as evidenced by numerous family and twin studies. Over the past two and a half decades, our laboratory has co-discovered the three early-onset familial AD genes, APP, PSEN1, and PSEN2, which can carry any of 200 fully penetrant mutations characterized by mendelian inheritance. For late-onset AD, the only well-established risk factor is the epsilon 4 variant of APOE, which increases risk by 3.7-fold in the heterozygous state and 10-fold when two copies are inherited. It has been estimated that 50-70% of the genetic variance of AD remains unexplained by the four established AD genes. We are engaged in two major efforts to identify the additional AD genes as part of our Alzheimer's Genome Project funded by the Cure Alzheimer's Fund. First, for published AD candidate genes, we have developed the AlzGene.org website, a comprehensive, online encyclopedia and database, which includes data on 650 AD candidate genes and 3000 DNA variants that have been tested for association with AD. For all DNA variants tested in at least four independent samples (300), AlzGene.org provides meta-analyses to determine the most promising AD candidate genes. These studies have led to over 40 candidate AD genes, including APOE, that yield significant results. However, the effects of these variants on risk are tiny compared to APOE
We are currently exploring whether these associations are being driven by rare late-onset AD mutations in linkage disequilibrium with the disease-associated common variants. We found this to be the case for the APP alpha-secretase gene, ADAM10,in which we discovered two rare mutations that severely impair ADAM10 cleavage of APP both in vitro and in transgenic mice. Second, in a parallel effort, we have carried out several genome-wide association studies on 800 well-characterized late-onset AD families (NIMH and NCRAD samples) using Affymetrix genotyping arrays containing either one million (6.0) or 500,000 (5.0) genomic single nucleotide polymorphisms (SNPs) as well as arrays containing 20,000 coding SNPs. We have previously reported four novel loci that achieved genome-wide significance (besides APOE) including a novel gene on chromosome 14q, GWA-14q, the ataxin 1 gene, the innate immune system lectin gene, CD33, and the synaptic gene, DLGAP1.
Functional studies of the ATXN1 gene carried out both in vitro and in vivo in ATXN1 knockout mice show that ATXN1 can regulate Ab levels via modulation of beta-secretase. We will also present new data implicating Ab as an anti-microbial peptide in the innate immune system. These latter data in combination with several novel candidate genes emanating from the Alzheimer's Genome Project suggest that innate immune system in the brain may play a central role in the etiology and pathogenesis of AD, raising new possibilities for novel drug discovery. Along these lines, I will present data on several promising therapeutics aimed at preventing and treating AD based on knowledge gained from AD genes.
The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
For more information, visit:
http://wals.od.nih.gov/
Author: Dr. Rudolph Tanzi, Harvard Medical School
Runtime: 01:13:34
Permanent link: http://videocast.nih.gov/launch.asp?16548
Young Hope: Living With Early Onset Alzheimer'sThis film has been entered into the 2010 Neuro Film Festival from the American Academy of Neurology Foundation at www.neurofilmfestival.com. Let's put our brains together and support brain research!
A short documentary about my friend Tracy.
2nd upload...I noticed a major glitch in the 1st upload...please repost.
Memory Moments: Early-onset Familial Alzheimer'sts hard enough to imagine losing your memory in your eighties or nineties. But Imagine losing it at fifty. Then imagine you could pass that risk on to your kids.
Sisters Nikole and Kersten. A dad who loves them, and a mom who may or may not know who they are. A just fifty, Kay Anderson developed what's called early-onset familial Alzheimer's.
Mark is Kay's husband. He and the girls visit their mom at Lakeview Ranch. A care facility in Dassel/Darwin Minnesota the family calls a Godsend.
To learn more visit:
http://www.lakeviewranch.com
To donate for a good cause visit:
htt://www.dementiacarefoundation.org
If you would but to tell your story visit:
http://www.brilliantimageproductions.com
...
Battling with Alzheimer's disease: Zahra Moussavi at TEDxWinnipegBattling with Alzheimer's Disease: Ideas on early detection, treatment and prevention: Zahra Moussavi at TEDxWinnipeg
For decades the conventional wisdom of neuroscience held that our brain is hardwired, fixed and immutable, but new findings in the last 20 years leave no doubt that - on the contrary - our brain is dramatically plastic; it can adapt, rewire, heal, renew, and, even into old age, not only change its structure but also generate new neurons. It is important to realize that as frightening as Alzheimer disease is, according to Dr. Whitehouse, a prominent neuropsychologist at Johns Hopkins University, "it is not even a single condition to be called a disease; therefore searching only for biological solutions (i.e., medications, gene therapies) is a false hope." We have to think of brain health and preventing dementia as a lifetime perspective that pays much more attention to the quality of our environment than the quality of our genes. The key to future solutions for healthy brain aging is going to be a multidisciplinary approach. We know that significant rehabilitation changes in the brain can occur across life - basically to the end of life.
Dr. Moussavi is a Canada Research Chair in Biomedical Engineering with special interest in early diagnosis of Alzheimer's and neurorehabilitation. She is also an expert in sleep apnea and respiratory sounds analysis. Human diseases and neurological disorders are betrayed by symptoms that can be detected by biomedical technologies. Dr. Moussavi has developed novel technologies to be used for early detection of dementia in general and Alzheimer in particular, home-care devices for rehabilitation of people with spinal cord injuries, quick and simple screening methods for sleep apnea detection during wakefulness and also non-invasive technique for detecting swallowing disorders. As varied as her focused research area may seem, they all share the same thread of development of biomedical technologies for non-invasive and early detection of diseases that are challenging to be diagnosed. The key outcome of her works is to improve quality of life especially for aging population.
In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)
Alzheimer's DiseaseBruce Reed, the Associate Director of the Alzheimer's Disease Research Center at UC Davis presents a comprehensive update on Alzhemier's Disease. What is Alzhemier's Disease and can it be cured or treated? Can one predict who will ultimately be afflicted by this disease? What is the current research being done on Alzheimier's Disease? Series: "The Coming of Age Lecture Series" [5/2008] [Health and Medicine] [Show ID: 14217]
What's the Difference Between Alzheimer's Disease and Dementia?FreeDem Videos Hope to Boost Ireland's Brain Health and Tackle Fears About Memory Loss
10 quirky animated videos addressing common concerns about memory loss and dementia have been developed by researchers in Trinity College Dublin in a bid to allay fears about memory loss, promote brain health and tackle the stigma associated with dementia.
http://www.tcd.ie
http://freedemliving.com/
Alzheimer's Long and Costly Goodbye -- Heartache and Hope: America's Alzheimer's Epidemic (Ep. 1)(Visit: http://www.uctv.tv/alzheimers) As Baby Boomers become senior citizens, Alzheimer's Disease and other forms of dementia are on track to reach epidemic proportions, with a new case every 68 seconds and an annual cost of $1.2 trillion projected by 2050. The disease also takes its toll on family members struggling to care for their loved ones, while watching them slowly slip away in what some describe as "the long goodbye."
The first in a series of three programs from UCLA offers an overview of the looming epidemic and illustrates the fear and grief experienced by patients and their loved ones, including Patti Davis, daughter of Ronald Reagan, and TV personality Leeza Gibbons, who lost her mother to Alzheimer's. Series: "Alzheimer's Disease Programs" [Health and Medicine] [Show ID: 23903]
http://www.uctv.tv/prime
Alzheimer's DiseaseThe challenges of Alzheimer's Disease for both the patient and caregiver.
Mechanisms and secrets of Alzheimer's disease: exploring the brainA scientific film with a 3D modeling made on the inner mechanisms of the brain implicated in the development of Alzheimer's disease. Available in English, German, French and Dutch produced by Internationale Stichting Alzheimer Onderzoek (ISAO) (NL), Alzheimer Forschung Initiative e.V. (AFI) (D) and La Ligue Européenne Contre la Maladie d'Alzheimer (LECMA) (FR). www.alzheimer-research.eu.
Alzheimer's Disease: Overview and Current ResearchAllan Levey, MD, PhD, professor and chair of the Department of Neurology at the School of Medicine and director of Emory's Alzheimer's Disease Research Center, talks about the latest research on this crippling disease (April 23, 2013).
His talk was sponsored by the Center for the Study of Human Health, which was established to centralize and organize Emory's vast resources in health-related studies. The Center provides a home for a unique interdisciplinary undergraduate curricula, as well as a place where faculty can develop groundbreaking programs and research.
http://humanhealth.emory.edu/home
http://news.emory.edu/tags/expert/allan_levey/
Stages of Alzheimer's Disease (Alzheimers #2)Alzheimer's disease follows a general pattern as it worsens over time. Learn what to expect as this common disease runs its course.Watch More Health Videos at Health Guru: http://www.healthguru.com/?YT
![Inside the Brain: Unraveling the Mystery of Alzheimer's Disease [HQ]](https://img.youtube.com/vi/NjgBnx1jVIU/mqdefault.jpg)
