Vidalista Black 80 mg works by inhibiting phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate (cGMP), a chemical that promotes blood flow. By inhibiting PDE5, tadalafil enhances the action of nitric oxide, a vasodilator that relaxes blood vessels, allowing increased blood flow. This mechanism not only supports penile erection but also has broader implications for systemic circulation.