Tadarise 20 is typically taken orally, usually about 30 minutes to 1 hour before anticipated sexual activity. The effects of Tadarise 20 can last for up to 36 hours, earning it the nickname "the weekend pill." This prolonged duration of action is one of the distinguishing features of Tadalafil compared to other ED medications like sildenafil (Viagra) or vardenafil (Levitra).