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The aryl hydrocarbon receptor (AHR), a member of the basic helix-loop-helix (b-HLH) transcription factor, is a regulatory protein broadly expressed in human tissues. AHR tends to be highly expressed in lung and liver, the main human contacting and metabolic organs of toxins, and plays significant roles in detoxification of aryl toxins. Increasing evidence suggests that AHR is involved in the pathogenesis of multiple diseases, such as cardiovascular diseases, Akt-targeting PROTAC www.creative-biolabs.com/protac/ligand-design-for-akt-targeting-protac.htm
